133rd Annual Shattuck Lecture - Assessing Therapeutic Responses in Infectious Disease
The primary objective of anti-infective drug treatment is to save life in life-threatening illness, and control or clear the infection as safely and rapidly as possible in less serious infections. Prevention of spread and resistance are important secondary
considerations. Serial quantitation of the pathogen in body fluids allows pharmacometric evaluation and informs choice of drug and optimization of dose and duration of therapy. Parasitic, fungal, and viral infections can often be quantitated accurately
in-vivo and evaluated in this way. This Lecture (recorded on May 24, 2023) focuses primarily on the treatment of malaria and COVID-19 as examples.
Faculty
Shattuck Lecturer
Nicholas John White, OBE, KCMG, MD, DSc, FRCP, FMedSci, FBPhS, FRS
Professor of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Thailand & Oxford University, UK
Consultant Physician, Acute General Medicine, John Radcliffe Hospital, Oxford
Wellcome Trust Principal Research Fellow; Chair, Wellcome Trust Tropical Medicine Research Programmes, South East Asia
Professor Sir Nicholas John White, FRS, is Professor of Tropical Medicine at the Faculty of Tropical Medicine, Mahidol University, Thailand and at Oxford University, UK. He is also a Consultant Physician in acute general medicine at the John Radcliffe
Hospital, Oxford. Professor White is a Wellcome Trust Principal Research Fellow who chairs the Wellcome Trust Tropical Medicine Research Programmes in South East Asia. He has conducted research across a broad range of infectious diseases. His main
research focus is the pathophysiology and treatment of malaria. He has authored over 1250 scientific publications and over 50 book chapters. His “h” index is currently 150 (Scopus) and 200 (Google). Professor White has received the Prince Mahidol
Prize for Medicine, the Canada Gairdner Foundation Global Health Prize, and the Royal Society of Tropical Medicine and Hygiene Manson medal. He co-chaired the WHO antimalarial treatment guidelines committee for twelve years and he currently chairs
the Scientific Advisory Committee of the Drugs for Neglected Diseases initiative and the COVID-19 Clinical Research Coalition.
Moderator
Eric J. Rubin, MD, PhD
Editor-in-Chief, New England Journal of Medicine, NEJM Group
Dr. Rubin joined the New
England Journal of Medicine (NEJM) and NEJM Group as Editor-in-Chief in September 2019, taking on the responsibility for oversight of all editorial content and policies. Dr. Rubin is an Associate Physician specializing in infectious disease at Brigham
and Women’s Hospital and is a Professor in the Department of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health. He serves on several scientific advisory boards to groups interested in infectious disease therapeutics.
Dr. Rubin has also previously served as the Associate Editor for Infectious Disease at the New England Journal of Medicine as well as an editor for several basic science journals including PLoS Pathogens, Tuberculosis, and mBio.
Course Objectives
Upon completion of this activity, learners should be able to:
- Identify methods that may be used to quantitate infections in-vivo
- Interpret results of evaluation data to guide decisions on optimal therapeutic treatments
- Describe how pharmacometrics characterization informs drug development
Course Fees
Massachusetts Medical Society (MMS) Physician Member: $40.00
MMS Resident/Student Member: Free
Non-Member Physician: $90.00
Non-Members Resident/Student: $20.00
Allied Health Professional/Other: $32.00
Format & Estimated Time to Complete
Video, 1 hour
Accreditation and Credit Information
Accreditation Statement
The Massachusetts Medical Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education
for physicians.
AMA Credit Designation Statement
The Massachusetts Medical Society designates this enduring material for a maximum of 1.00 AMA PRA Category 1
Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
National Commission on Certification of Physician Assistants (NCCPA)
Physician Assistants may claim a maximum of 1.00 Category 1 credits for completing this activity. NCCPA accepts AMA PRA
Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.
Exam/Assessment: A score of 70% or higher is required to receive AMA PRA Category 1 Credit™.
Activity Term
Original Release Date: May 31, 2023
Review Date (s): N/A
Termination Date: May 31, 2026
System Requirements
Desktops/Laptops
Windows 10
Mac OSX 10.6 higher
Most modern browsers including:
IE 11+
Firefox 18.0+
Chrome latest version
Safari 12+
Mobile/Tablet
iOS devices beginning with OS version 10 or higher (includes, iPhone, ipad and iTouch devices)
